red_array mt_header  
computational systems biology

 
 
StarNet Result
Central node
Entrez Gene ID Official Gene Symbol Unofficial Synonyms Description
15110 Hand1 Ehand1, Hxt, Th1, Thing1, eHAND heart and neural crest derivatives expressed transcript 1
Parameters: ID provided: HAND1 [symbol], Max. levels: 2, Network type: highestInternal, Drawn with: symbol, Node type: ellipse, Node style: filled, Dist.: genecentric, Correlations considered: posneg, Common genes shown: true, Edges labeled with correlations: false, Drawn with: splines, Levels color scheme: pastel, cdf9_1, Highlighted GO terms: transcription
Notifications
Full cohort correlation network
Cardiac cohort correlation network

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Click on a network to view a full size image with node links to Entrez Gene.
 
Line colors represent strength of Pearson correlation coefficients based on the following scale
full scale   cardiac scale
 
Node color represents the level with respect to the central node

level scale
The graphs below show known interactions involving genes from the correlation networks above. Gene names in blue correspond to genes from the correlation networks above.
Black lines: protein-protein interactions, red arrows: protein->DNA interactions. For a full legend of edges, see the User Manual.
Full cohort known interactions
Cardiac cohort known interactions

NoFull.png NoCardiac.png

Full cohort: gene list | edge list | known interactions | GO search term matches | Enriched GO terms
Cardiac cohort: gene list | edge list | known interactions | GO search term matches | Enriched GO terms
Gene list: full cohort
Entrez Gene ID Official Gene Symbol Unofficial Synonyms Description Appears in both networks
12338 Capn6-calpain 6 No
12416 Cbx2M33, MOD2, pcchromobox homolog 2 (Drosophila Pc class) No
12627 Cfc1AV265756, crypticcripto, FRL-1, cryptic family 1 No
13389 Dll3pu, pudgydelta-like 3 (Drosophila) No
14008 Etv2Etsrp71ets variant gene 2 No
14106 Foxh1Fast2forkhead box H1 No
14634 Gli3AI854843, AU023367, Bph, Pdn, Xt, addGLI-Kruppel family member GLI3 No
15110 Hand1Ehand1, Hxt, Th1, Thing1, eHANDheart and neural crest derivatives expressed transcript 1 Yes
16002 Igf2AL033362, Igf-2, Igf-II, M6pr, Mpr, Peg2insulin-like growth factor 2 No
17261 Mef2dC80750, MGC31718myocyte enhancer factor 2D No
17292 Mesp1MGC159208, MGC159210mesoderm posterior 1 No
17294 MestAA408879, AI256745, Peg1mesoderm specific transcript No
17690 Msi1Msi1h, Musahi1, m-Msi-1Musashi homolog 1(Drosophila) No
17701 Msx1AA675338, AI324650, Hox-7, Hox7, Hox7.1, mshhomeo box, msh-like 1 No
17702 Msx2BB122635, Hox-8, Hox8, Hox8.1homeo box, msh-like 2 No
18124 Nr4a3AI573420, CHN, CSMF, MINOR, NOR-1, Nor1, TECnuclear receptor subfamily 4, group A, member 3 No
18741 Pitx29430085M16Rik, Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshinpaired-like homeodomain transcription factor 2 No
21677 Tead2ETF, Etdf, TEAD-2, TEF-4, TEF4TEA domain family member 2 No
22113 Phlda2Ipl, Tssc3pleckstrin homology-like domain, family A, member 2 No
27217 Mixl1Mm1, MmlMix1 homeobox-like 1 (Xenopus laevis) No
65255 Asb48430401O13Rik, AV117194, AW060255ankyrin repeat and SOCS box-containing protein 4 No
72522 Atxn7l22610528J18Rikataxin 7-like 2 No
83557 Lin28AL024421, Lin-28, Lin28a, Tex17lin-28 homolog (C. elegans) No
100470 Lao1AW990848L-amino acid oxidase 1 No
140486 Igf2bp1AL024068, AW549074, CRD-BP, Crdbp, D030026A21Rik, D11Moh45, IMP-1, Neilsen, Zbp1insulin-like growth factor 2 mRNA binding protein 1 No
277154 BC030046AA409373, C80530, KIAA1305, mKIAA1305cDNA sequence BC030046 No
333564 Gm784Fndc3c, MGC100196, MGC100347gene model 784, (NCBI) No
Edge list: full cohort
Gene pairs Pearson Corr. Coefficient 95% Confidence Interval 99% Confidence Interval
Hand1 [15110] ---- Foxh1 [14106] 0.55489 (n=2145) [0.5249, 0.5835] [0.5151, 0.5923]
Hand1 [15110] ---- Cfc1 [12627] 0.54080 (n=2145) [0.5102, 0.5701] [0.5002, 0.5790]
Hand1 [15110] ---- Phlda2 [22113] 0.52197 (n=2145) [0.4905, 0.5521] [0.4802, 0.5613]
Hand1 [15110] ---- BC030046 [277154] 0.50625 (n=2145) [0.4741, 0.5371] [0.4636, 0.5465]
Hand1 [15110] ---- Msx1 [17701] 0.47779 (n=2145) [0.4445, 0.5098] [0.4336, 0.5197]
Foxh1 [14106] ---- Nr4a3 [18124] 0.59976 (n=2145) [0.5720, 0.6262] [0.5629, 0.6343]
Foxh1 [14106] ---- Msi1 [17690] 0.59488 (n=2145) [0.5668, 0.6216] [0.5577, 0.6297]
Foxh1 [14106] ---- Lao1 [100470] 0.58955 (n=2145) [0.5612, 0.6165] [0.5520, 0.6247]
Foxh1 [14106] ---- Atxn7l2 [72522] 0.58504 (n=2145) [0.5565, 0.6122] [0.5472, 0.6205]
Foxh1 [14106] ---- Mef2d [17261] 0.58385 (n=2145) [0.5552, 0.6111] [0.5459, 0.6194]
Cfc1 [12627] ---- Hand1 [15110] 0.54080 (n=2145) [0.5102, 0.5701] [0.5002, 0.5790]
Cfc1 [12627] ---- Etv2 [14008] 0.53372 (n=2145) [0.5028, 0.5633] [0.4927, 0.5724]
Cfc1 [12627] ---- Foxh1 [14106] 0.49095 (n=2145) [0.4581, 0.5224] [0.4475, 0.5321]
Cfc1 [12627] ---- Mesp1 [17292] 0.48206 (n=2145) [0.4489, 0.5139] [0.4381, 0.5237]
Cfc1 [12627] ---- Mixl1 [27217] 0.45210 (n=2145) [0.4178, 0.4851] [0.4067, 0.4953]
Phlda2 [22113] ---- Lin28 [83557] 0.55237 (n=2145) [0.5223, 0.5811] [0.5124, 0.5899]
Phlda2 [22113] ---- Dll3 [13389] 0.54530 (n=2145) [0.5149, 0.5744] [0.5049, 0.5833]
Phlda2 [22113] ---- Igf2bp1 [140486] 0.54073 (n=2145) [0.5101, 0.5700] [0.5001, 0.5790]
Phlda2 [22113] ---- Pitx2 [18741] 0.53366 (n=2145) [0.5027, 0.5633] [0.4926, 0.5723]
Phlda2 [22113] ---- Mesp1 [17292] 0.53055 (n=2145) [0.4994, 0.5603] [0.4893, 0.5694]
BC030046 [277154] ---- Tead2 [21677] 0.59349 (n=2145) [0.5654, 0.6202] [0.5562, 0.6284]
BC030046 [277154] ---- Asb4 [65255] 0.58155 (n=2145) [0.5528, 0.6089] [0.5435, 0.6172]
BC030046 [277154] ---- Igf2 [16002] 0.56610 (n=2145) [0.5366, 0.5942] [0.5270, 0.6028]
BC030046 [277154] ---- Mest [17294] 0.55729 (n=2145) [0.5274, 0.5858] [0.5177, 0.5945]
BC030046 [277154] ---- Capn6 [12338] 0.54010 (n=2145) [0.5094, 0.5694] [0.4994, 0.5784]
Msx1 [17701] ---- Gli3 [14634] 0.54937 (n=2145) [0.5191, 0.5782] [0.5093, 0.5871]
Msx1 [17701] ---- Cbx2 [12416] 0.52078 (n=2145) [0.4892, 0.5510] [0.4790, 0.5602]
Msx1 [17701] ---- Gm784 [333564] 0.52014 (n=2145) [0.4886, 0.5503] [0.4783, 0.5596]
Msx1 [17701] ---- Foxh1 [14106] 0.51365 (n=2145) [0.4818, 0.5441] [0.4714, 0.5535]
Msx1 [17701] ---- Msx2 [17702] 0.50333 (n=2145) [0.4710, 0.5343] [0.4606, 0.5438]
Known interactions: full cohort
Gene Symbol 1 [Entrez ID] Description 1 Gene Symbol 2 [Entrez ID] Description 2 Interaction type Gene RIF PubMed reference DB source
Foxh1 [14106] forkhead box H1 Nkx2-5 [18091] NK2 transcription factor related, locus 5 protein - protein Foxh1 interacts with Nkx2-5. 15363409 BIND
Foxh1 [14106] forkhead box H1 Mef2c [17260] Mus musculus chromosome 13 genomic contig, strain C57BL/6J protein - dna Foxh1 binds Mef2c-FNE intronic enhancer element. 15363409 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Hand2 [15111] Mus musculus dHAND mRNA, and translated products protein - protein Hand1 heterodimerizes with Hand2. 15735646 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Hand1 [15110] heart and neural crest derivatives expressed transcript 1 protein - protein Hand1 homodimerizes. 15735646 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Tcf12 [21406] transcription factor 12 protein - protein Tcf12 interacts with Th1. This interaction was modeled on a demonstrated interaction between Drosophila Da and mouse Th1. 7791788 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Twist1 [22160] twist gene homolog 1 protein - protein Twist1 heterodimerizes with Hand1. 15735646 BIND
Mef2d [17261] myocyte enhancer factor 2D Cabin1 [104248] PREDICTED: calcineurin binding protein 1 protein - protein MEF2D interacts with CABIN1. 15902271 BIND
Dlx2 [13392] distal-less homeobox 2 Msx1 [17701] Msx1 protein protein - protein Dlx2 interacts with Msx1 9111364 BIND
Msx1 [17701] homeobox protein MSX1 variant Hist1h1b [56702] histone 1, H1b protein - protein Msx1 interacts with H1b. 15192231 BIND
Msx1 [17701] homeobox protein MSX1 variant Myod1 [17927] Mus musculus chromosome 7 genomic contig, strain C57BL/6J protein - dna Msx1 interacts with the core enhancer region (CER) of myoD. 15192231 BIND
Msx1 [17701] Msx1 protein Tbp [21374] TATA box binding protein protein - protein Msx1 interacts with TBP. This interaction was modelled on a demonstrated interaction between mouse Msx1 and human TBP. 8700832 BIND
Msx1 [17701] homeo box, msh-like 1 Pax9 [18511] paired box gene 9 protein - protein Pax9 interacts with Msx1. 15721141 BIND
Msx1 [17701] homeo box, msh-like 1 Gmnn [57441] geminin protein - protein Gem interacts with truncated Msx1. 14973489 BIND
Phlda2 [22113] Mus musculus chromosome 7 Hist1h3a [360198] histone 1, H3a dna - protein Histone H3 interacts with Phlda2 gene. 15516931 BIND
Matches for GO search term(s) "transcription": full cohort
Official Gene Symbol Entrez Gene ID GO Terms
Cbx2 12416GO:0000122 GO:0006350 GO:0006355
Etv2 14008GO:0003700 GO:0006350 GO:0006355
Foxh1 14106GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0006357 GO:0016563 GO:0045944
Gli3 14634GO:0006350 GO:0006355 GO:0016481 GO:0017053
Hand1 15110GO:0000122 GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0008134 GO:0016564 GO:0030528 GO:0045449 GO:0045944
Mef2d 17261GO:0003700 GO:0006350 GO:0006355 GO:0016563
Mesp1 17292GO:0030528 GO:0045449
Msx1 17701GO:0000122 GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0016564 GO:0045449 GO:0045892
Msx2 17702GO:0003700 GO:0005667 GO:0006355 GO:0045449
Nr4a3 18124GO:0003700 GO:0006350 GO:0006355
Pitx2 18741GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0008134 GO:0045449
Tead2 21677GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0016563 GO:0045944
Mixl1 27217GO:0003700 GO:0006350 GO:0006355
Asb4 65255GO:0003700 GO:0006355
Lin28 83557GO:0006355
Enriched GO terms: full cohort
GO Term GO ID raw p-value Symbols (Entrez IDs)
* DNA bindingGO:0003677 1.20E-09Hand1 (15110), Foxh1 (14106), BC030046 (277154), Msx1 (17701), Nr4a3 (18124), Mef2d (17261), Etv2 (14008), Mixl1 (27217), Lin28 (83557), Pitx2 (18741), Tead2 (21677), Asb4 (65255), Gli3 (14634), Cbx2 (12416), Msx2 (17702)
* sequence-specific DNA bindingGO:0043565 5.74E-09Foxh1 (14106), Msx1 (17701), Nr4a3 (18124), Mef2d (17261), Etv2 (14008), Mixl1 (27217), Pitx2 (18741), Gli3 (14634), Msx2 (17702)
* transcription factor activityGO:0003700 1.04E-08Hand1 (15110), Foxh1 (14106), Msx1 (17701), Nr4a3 (18124), Mef2d (17261), Etv2 (14008), Mixl1 (27217), Pitx2 (18741), Tead2 (21677), Asb4 (65255), Msx2 (17702)
* regulation of transcription, DNA-dependentGO:0006355 3.76E-08Hand1 (15110), Foxh1 (14106), Msx1 (17701), Nr4a3 (18124), Mef2d (17261), Etv2 (14008), Mixl1 (27217), Lin28 (83557), Pitx2 (18741), Tead2 (21677), Asb4 (65255), Gli3 (14634), Cbx2 (12416), Msx2 (17702)
* transcriptionGO:0006350 8.87E-07Hand1 (15110), Foxh1 (14106), Msx1 (17701), Nr4a3 (18124), Mef2d (17261), Etv2 (14008), Mixl1 (27217), Pitx2 (18741), Tead2 (21677), Gli3 (14634), Cbx2 (12416)
* transcription factor complexGO:0005667 6.78E-06Hand1 (15110), Foxh1 (14106), Msx1 (17701), Pitx2 (18741), Tead2 (21677), Msx2 (17702)
* embryonic limb morphogenesisGO:0030326 1.81E-05Msx1 (17701), Gli3 (14634), Msx2 (17702)
* heart developmentGO:0007507 1.82E-05Hand1 (15110), Mixl1 (27217), Pitx2 (18741), Gli3 (14634)
* gastrulationGO:0007369 1.98E-05Cfc1 (12627), Mixl1 (27217)
* nucleusGO:0005634 2.41E-05Hand1 (15110), Foxh1 (14106), Msx1 (17701), Nr4a3 (18124), Msi1 (17690), Mef2d (17261), Etv2 (14008), Mesp1 (17292), Mixl1 (27217), Igf2bp1 (140486), Pitx2 (18741), Tead2 (21677), Gli3 (14634), Cbx2 (12416), Msx2 (17702)
* mesoderm formationGO:0001707 1.79E-04Hand1 (15110), Nr4a3 (18124)
* multicellular organismal developmentGO:0007275 3.29E-04Hand1 (15110), Cfc1 (12627), Msx1 (17701), Dll3 (13389), Pitx2 (18741), Msx2 (17702)
* regulation of transcriptionGO:0045449 3.56E-04Hand1 (15110), Msx1 (17701), Mesp1 (17292), Pitx2 (18741), Msx2 (17702)
* negative regulation of transcription from RNA polymerase II promoterGO:0000122 4.63E-04Hand1 (15110), Msx1 (17701), Cbx2 (12416)
* determination of left/right symmetryGO:0007368 4.94E-04Foxh1 (14106), Pitx2 (18741)
* transcriptional activator activityGO:0016563 5.91E-04Foxh1 (14106), Mef2d (17261), Tead2 (21677)
head involutionGO:0008258 8.30E-04Mesp1 (17292)
activin responsive factor complexGO:0032444 8.30E-04Foxh1 (14106)
optic nerve morphogenesisGO:0021631 8.30E-04Gli3 (14634)
gut developmentGO:0048565 8.30E-04Mixl1 (27217)
mesodermal cell migrationGO:0008078 8.30E-04Mesp1 (17292)
* anterior/posterior pattern formationGO:0009952 1.46E-03Foxh1 (14106), Gli3 (14634)
* positive regulation of transcription from RNA polymerase II promoterGO:0045944 1.50E-03Hand1 (15110), Foxh1 (14106), Tead2 (21677)
embryonic heart tube anterior/posterior pattern formationGO:0035054 1.66E-03Foxh1 (14106)
smoothened signaling pathway involved in ventral spinal cord interneuron specificationGO:0021775 1.66E-03Gli3 (14634)
tube developmentGO:0035295 1.66E-03Gli3 (14634)
prothoracicotrophic hormone activityGO:0018445 1.66E-03Igf2 (16002)
amino acid catabolic processGO:0009063 1.66E-03Lao1 (100470)
paraxial mesoderm developmentGO:0048339 1.66E-03Dll3 (13389)
L-amino-acid oxidase activityGO:0001716 1.66E-03Lao1 (100470)
axial mesoderm developmentGO:0048318 1.66E-03Foxh1 (14106)
smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationGO:0021776 1.66E-03Gli3 (14634)
* forebrain developmentGO:0030900 1.71E-03Msx1 (17701), Gli3 (14634)
* pattern specification processGO:0007389 2.43E-03Pitx2 (18741), Gli3 (14634)
hindgut morphogenesisGO:0007442 2.49E-03Gli3 (14634)
embryonic gut morphogenesisGO:0048558 2.49E-03Gli3 (14634)
polysomeGO:0005844 2.49E-03Msi1 (17690)
extraocular skeletal muscle developmentGO:0002074 2.49E-03Pitx2 (18741)
poly(U) bindingGO:0008266 2.49E-03Msi1 (17690)
compartment specificationGO:0007386 3.32E-03Dll3 (13389)
embryonic gut developmentGO:0048566 3.32E-03Gli3 (14634)
* transcription factor bindingGO:0008134 3.54E-03Hand1 (15110), Pitx2 (18741)
anatomical structure formationGO:0048646 4.15E-03Gli3 (14634)
developmental growthGO:0048589 4.15E-03Gli3 (14634)
insulin-like growth factor receptor bindingGO:0005159 4.15E-03Igf2 (16002)
spinal cord dorsal-ventral patterningGO:0021513 4.15E-03Gli3 (14634)
neural tube developmentGO:0021915 4.15E-03Gli3 (14634)
anatomical structure developmentGO:0048856 4.98E-03Gli3 (14634)
embryonic morphogenesisGO:0048598 5.81E-03Gli3 (14634)
* transcriptional repressor activityGO:0016564 5.99E-03Hand1 (15110), Msx1 (17701)
* chromatin bindingGO:0003682 6.11E-03Gli3 (14634), Cbx2 (12416)
DNA integrationGO:0015074 6.64E-03BC030046 (277154)
PcG protein complexGO:0031519 6.64E-03Cbx2 (12416)
Notch bindingGO:0005112 6.64E-03Dll3 (13389)
single-stranded RNA bindingGO:0003727 6.64E-03Msi1 (17690)
transcriptional repressor complexGO:0017053 7.47E-03Gli3 (14634)
proximal/distal pattern formationGO:0009954 7.47E-03Gli3 (14634)
camera-type eye morphogenesisGO:0048593 8.30E-03Gli3 (14634)
midbrain developmentGO:0030901 9.13E-03Msx1 (17701)
mammary gland developmentGO:0030879 9.96E-03Gli3 (14634)
cell fate determinationGO:0001709 9.96E-03Dll3 (13389)
* organ morphogenesisGO:0009887 1.04E-02Phlda2 (22113), Igf2 (16002)
SMAD bindingGO:0046332 1.08E-02Foxh1 (14106)
regulation of cell differentiationGO:0045595 1.08E-02Gli3 (14634)
neuron fate commitmentGO:0048663 1.16E-02Gli3 (14634)
heart morphogenesisGO:0003007 1.16E-02Mesp1 (17292)
endoderm developmentGO:0007492 1.16E-02Mixl1 (27217)
protein domain specific bindingGO:0019904 1.24E-02Foxh1 (14106)
ureteric bud branchingGO:0001658 1.24E-02Gli3 (14634)
metanephros developmentGO:0001656 1.24E-02Gli3 (14634)
calpain activityGO:0004198 1.24E-02Capn6 (12338)
smoothened signaling pathwayGO:0007224 1.24E-02Gli3 (14634)
patterning of blood vesselsGO:0001569 1.41E-02Pitx2 (18741)
negative regulation of cell differentiationGO:0045596 1.49E-02Gli3 (14634)
kidney developmentGO:0001822 1.66E-02Gli3 (14634)
branching morphogenesis of a tubeGO:0048754 1.83E-02Gli3 (14634)
* transcription regulator activityGO:0030528 2.05E-02Hand1 (15110), Mesp1 (17292)
somitogenesisGO:0001756 2.07E-02Dll3 (13389)
regulation of cell migrationGO:0030334 2.32E-02Pitx2 (18741)
transforming growth factor beta receptor signaling pathwayGO:0007179 2.41E-02Foxh1 (14106)
odontogenesis (sensu Vertebrata)GO:0042475 2.49E-02Gli3 (14634)
dorsal/ventral pattern formationGO:0009953 2.57E-02Gli3 (14634)
chromatin assembly or disassemblyGO:0006333 2.65E-02Cbx2 (12416)
aminopeptidase activityGO:0004177 2.82E-02Mest (17294)
regulation of translationGO:0006417 2.99E-02Igf2bp1 (140486)
central nervous system developmentGO:0007417 2.99E-02Gli3 (14634)
muscle developmentGO:0007517 3.32E-02Msx1 (17701)
Notch signaling pathwayGO:0007219 3.65E-02Dll3 (13389)
lung developmentGO:0030324 3.81E-02Gli3 (14634)
ligand-dependent nuclear receptor activityGO:0004879 3.81E-02Nr4a3 (18124)
steroid hormone receptor activityGO:0003707 4.39E-02Nr4a3 (18124)
regulation of cell proliferationGO:0042127 4.72E-02Pitx2 (18741)
negative regulation of transcription, DNA-dependentGO:0045892 4.89E-02Msx1 (17701)
in utero embryonic developmentGO:0001701 4.89E-02Dll3 (13389)
Gene list: cardiac cohort
Entrez Gene ID Official Gene Symbol Unofficial Synonyms Description Appears in both networks
13345 Twist2Dermo1twist homolog 2 (Drosophila) No
14184 Fgfr3Fgfr-3, HBGFRfibroblast growth factor receptor 3 No
14734 Gpc3OCI-5glypican 3 No
15110 Hand1Ehand1, Hxt, Th1, Thing1, eHANDheart and neural crest derivatives expressed transcript 1 Yes
15394 Hoxa1ERA1, Hox-1.6homeo box A1 No
15414 Hoxb6Hox-2.2homeo box B6 No
15429 Hoxd1Hox-4.9homeo box D1 No
15437 Hoxd84921540P06Rik, AI047735, Hox-4.3, Hox-5.4homeo box D8 No
18616 Peg3AL022617, End4, Gcap4, Pw1, Zfp102, mKIAA0287paternally expressed 3 No
20204 Prrx2Prx2, S8paired related homeobox 2 No
20583 Snai2Slug, Slugh, Snail2snail homolog 2 (Drosophila) No
53614 ReckSt15, mRECKreversion-inducing-cysteine-rich protein with kazal motifs No
94275 Maged12810433C11Rik, 5430405L04Rik, DXBwg1492e, Dlixin, Dlxin-1, Dlxin1, FLJ00163, NRAGE, mFLJ00163melanoma antigen, family D, 1 No
140709 Emid29430032K24Rik, BC002218, Col26a, Col26a1, Emu2, MGC7475EMI domain containing 2 No
140792 Colec12CL-P1, SRCL, Scara4collectin sub-family member 12 No
230761 BC039093-cDNA sequence BC039093 No
278240 Spin2BC068162, MGC93001spindlin family, member 2 No
Edge list: cardiac cohort
Gene pairs Pearson Corr. Coefficient 95% Confidence Interval 99% Confidence Interval
Hand1 [15110] ---- Snai2 [20583] 0.75101 (n=239) [0.6899, 0.8015] [0.6681, 0.8155]
Hand1 [15110] ---- Spin2 [278240] 0.73366 (n=239) [0.6691, 0.7873] [0.6462, 0.8021]
Hand1 [15110] ---- Hoxb6 [15414] 0.72752 (n=239) [0.6617, 0.7822] [0.6384, 0.7974]
Hand1 [15110] ---- Peg3 [18616] 0.70922 (n=239) [0.6399, 0.7671] [0.6155, 0.7832]
Hand1 [15110] ---- Reck [53614] 0.69830 (n=239) [0.6270, 0.7580] [0.6018, 0.7747]
Snai2 [20583] ---- Reck [53614] 0.87504 (n=239) [0.8416, 0.9018] [0.8294, 0.9091]
Snai2 [20583] ---- Twist2 [13345] 0.83402 (n=239) [0.7908, 0.8690] [0.7752, 0.8785]
Snai2 [20583] ---- Spin2 [278240] 0.81923 (n=239) [0.7727, 0.8570] [0.7559, 0.8674]
Snai2 [20583] ---- Emid2 [140709] 0.80448 (n=239) [0.7546, 0.8451] [0.7367, 0.8563]
Snai2 [20583] ---- Peg3 [18616] 0.77014 (n=239) [0.7129, 0.8172] [0.6925, 0.8301]
Spin2 [278240] ---- Emid2 [140709] 0.86565 (n=239) [0.8299, 0.8943] [0.8169, 0.9021]
Spin2 [278240] ---- Hoxa1 [15394] 0.85714 (n=239) [0.8194, 0.8875] [0.8057, 0.8958]
Spin2 [278240] ---- Prrx2 [20204] 0.83740 (n=239) [0.7950, 0.8717] [0.7796, 0.8810]
Spin2 [278240] ---- Snai2 [20583] 0.81923 (n=239) [0.7727, 0.8570] [0.7559, 0.8674]
Spin2 [278240] ---- Reck [53614] 0.80445 (n=239) [0.7546, 0.8451] [0.7367, 0.8562]
Hoxb6 [15414] ---- Hoxd1 [15429] 0.80214 (n=239) [0.7518, 0.8432] [0.7337, 0.8545]
Hoxb6 [15414] ---- Snai2 [20583] 0.73249 (n=239) [0.6677, 0.7863] [0.6447, 0.8012]
Hoxb6 [15414] ---- Hand1 [15110] 0.72752 (n=239) [0.6617, 0.7822] [0.6384, 0.7974]
Hoxb6 [15414] ---- Fgfr3 [14184] 0.68779 (n=239) [0.6145, 0.7493] [0.5888, 0.7665]
Hoxb6 [15414] ---- Hoxd8 [15437] 0.66826 (n=239) [0.5915, 0.7330] [0.5647, 0.7511]
Peg3 [18616] ---- Reck [53614] 0.92571 (n=239) [0.9051, 0.9420] [0.8976, 0.9463]
Peg3 [18616] ---- Gpc3 [14734] 0.90422 (n=239) [0.8781, 0.9250] [0.8685, 0.9306]
Peg3 [18616] ---- Colec12 [140792] 0.85657 (n=239) [0.8187, 0.8870] [0.8049, 0.8953]
Peg3 [18616] ---- Maged1 [94275] 0.83689 (n=239) [0.7944, 0.8713] [0.7790, 0.8806]
Peg3 [18616] ---- BC039093 [230761] 0.82960 (n=239) [0.7854, 0.8654] [0.7694, 0.8752]
Reck [53614] ---- Peg3 [18616] 0.92571 (n=239) [0.9051, 0.9420] [0.8976, 0.9463]
Reck [53614] ---- Emid2 [140709] 0.88425 (n=239) [0.8531, 0.9091] [0.8417, 0.9159]
Reck [53614] ---- Prrx2 [20204] 0.87831 (n=239) [0.8457, 0.9044] [0.8338, 0.9115]
Reck [53614] ---- Snai2 [20583] 0.87504 (n=239) [0.8416, 0.9018] [0.8294, 0.9091]
Reck [53614] ---- Colec12 [140792] 0.87115 (n=239) [0.8368, 0.8987] [0.8242, 0.9062]
Known interactions: cardiac cohort
Gene Symbol 1 [Entrez ID] Description 1 Gene Symbol 2 [Entrez ID] Description 2 Interaction type Gene RIF PubMed reference DB source
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Hand2 [15111] Mus musculus dHAND mRNA, and translated products protein - protein Hand1 heterodimerizes with Hand2. 15735646 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Hand1 [15110] heart and neural crest derivatives expressed transcript 1 protein - protein Hand1 homodimerizes. 15735646 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Tcf12 [21406] transcription factor 12 protein - protein Tcf12 interacts with Th1. This interaction was modeled on a demonstrated interaction between Drosophila Da and mouse Th1. 7791788 BIND
Hand1 [15110] heart and neural crest derivatives expressed transcript 1 Twist1 [22160] twist gene homolog 1 protein - protein Twist1 heterodimerizes with Hand1. 15735646 BIND
Matches for GO search term(s) "transcription": cardiac cohort
Official Gene Symbol Entrez Gene ID GO Terms
Twist2 13345GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0006357 GO:0016564 GO:0030528 GO:0045449 GO:0045892
Hand1 15110GO:0000122 GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0008134 GO:0016564 GO:0030528 GO:0045449 GO:0045944
Hoxa1 15394GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0006357 GO:0045449
Hoxb6 15414GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0045449
Hoxd1 15429GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0045449
Hoxd8 15437GO:0003700 GO:0005667 GO:0006350 GO:0006355 GO:0045449
Prrx2 20204GO:0003700 GO:0005667 GO:0006355 GO:0045449
Snai2 20583GO:0006350 GO:0006355
Maged1 94275GO:0003713 GO:0006357
Enriched GO terms: cardiac cohort
GO Term GO ID raw p-value Symbols (Entrez IDs)
* transcription factor complexGO:0005667 1.01E-08Hand1 (15110), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* multicellular organismal developmentGO:0007275 5.87E-08Hand1 (15110), Snai2 (20583), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* regulation of transcriptionGO:0045449 7.14E-08Hand1 (15110), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* transcription factor activityGO:0003700 3.97E-06Hand1 (15110), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* organ morphogenesisGO:0009887 4.34E-06Hoxb6 (15414), Hoxd1 (15429), Hoxd8 (15437), Gpc3 (14734)
* pattern specification processGO:0007389 1.74E-05Hoxb6 (15414), Hoxd1 (15429), Hoxd8 (15437)
* sequence-specific DNA bindingGO:0043565 2.41E-05Hoxb6 (15414), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* DNA bindingGO:0003677 3.74E-05Hand1 (15110), Snai2 (20583), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* regulation of transcription from RNA polymerase II promoterGO:0006357 4.83E-05Twist2 (13345), Hoxa1 (15394), Maged1 (94275)
* regulation of transcription, DNA-dependentGO:0006355 6.61E-05Hand1 (15110), Snai2 (20583), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* transcriptionGO:0006350 6.86E-05Hand1 (15110), Snai2 (20583), Hoxb6 (15414), Twist2 (13345), Hoxa1 (15394), Hoxd1 (15429), Hoxd8 (15437)
* nucleusGO:0005634 1.40E-03Hand1 (15110), Snai2 (20583), Hoxb6 (15414), Peg3 (18616), Twist2 (13345), Hoxa1 (15394), Prrx2 (20204), Hoxd1 (15429), Hoxd8 (15437)
* phosphate transportGO:0006817 1.54E-03Emid2 (140709), Colec12 (140792)
blood vessel maturationGO:0001955 1.57E-03Reck (53614)
regulation of survival gene product activityGO:0045884 1.57E-03Snai2 (20583)
positive regulation of BMP signaling pathwayGO:0030513 1.57E-03Gpc3 (14734)
* negative regulation of cell proliferationGO:0008285 1.87E-03Fgfr3 (14184), Gpc3 (14734)
negative regulation of growthGO:0045926 2.09E-03Gpc3 (14734)
fibroblast growth factor receptor activityGO:0005007 2.09E-03Fgfr3 (14184)
* transcriptional repressor activityGO:0016564 2.37E-03Hand1 (15110), Twist2 (13345)
positive regulation of protein ubiquitinationGO:0031398 2.61E-03Fgfr3 (14184)
negative regulation of osteoblast differentiationGO:0045668 2.61E-03Twist2 (13345)
* GPI anchor bindingGO:0048503 2.71E-03Reck (53614), Gpc3 (14734)
peripheral to membrane of membrane fractionGO:0000300 3.13E-03Reck (53614)
internal side of plasma membraneGO:0009898 3.13E-03Fgfr3 (14184)
response to radiationGO:0009314 4.18E-03Snai2 (20583)
positive regulation of cell differentiationGO:0045597 4.70E-03Fgfr3 (14184)
fibroblast growth factor receptor signaling pathwayGO:0008543 5.74E-03Fgfr3 (14184)
positive regulation of peptidyl-tyrosine phosphorylationGO:0050731 6.26E-03Fgfr3 (14184)
gamete generationGO:0007276 6.79E-03Spin2 (278240)
ureteric bud branchingGO:0001658 7.83E-03Gpc3 (14734)
* transcription regulator activityGO:0030528 8.24E-03Hand1 (15110), Twist2 (13345)
hindbrain developmentGO:0030902 8.35E-03Hoxa1 (15394)
mesoderm formationGO:0001707 8.88E-03Hand1 (15110)
* proteinaceous extracellular matrixGO:0005578 1.08E-02Emid2 (140709), Gpc3 (14734)
MAPKKK cascadeGO:0000165 1.46E-02Fgfr3 (14184)
extracellular matrix organization and biogenesisGO:0030198 2.09E-02Reck (53614)
inner ear morphogenesisGO:0042472 2.30E-02Hoxa1 (15394)
positive regulation of apoptosisGO:0043065 2.51E-02Fgfr3 (14184)
anterior/posterior pattern formationGO:0009952 2.51E-02Hoxa1 (15394)
forebrain developmentGO:0030900 2.71E-02Fgfr3 (14184)
perinuclear region of cytoplasmGO:0048471 2.77E-02Fgfr3 (14184)
* cell differentiationGO:0030154 2.92E-02Hand1 (15110), Twist2 (13345)
* cell cycleGO:0007049 2.97E-02Spin2 (278240), Reck (53614)
negative regulation of transcription, DNA-dependentGO:0045892 3.08E-02Twist2 (13345)
transcription coactivator activityGO:0003713 3.55E-02Maged1 (94275)
negative regulation of progression through cell cycleGO:0045786 3.60E-02Reck (53614)
endopeptidase inhibitor activityGO:0004866 3.70E-02Reck (53614)
transcription factor bindingGO:0008134 3.91E-02Hand1 (15110)
protein heterodimerization activityGO:0046982 4.49E-02Hand1 (15110)
serine-type endopeptidase inhibitor activityGO:0004867 4.54E-02Reck (53614)
angiogenesisGO:0001525 4.85E-02Hand1 (15110)